Domperidone primarily targets dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and the gastrointestinal tract. Blocking these receptors prevents dopamine from inhibiting the release of acetylcholine and motilin.
This blockade increases lower esophageal sphincter pressure, accelerates gastric emptying, and enhances intestinal motility. The result? Faster transit of food through the digestive system, alleviating symptoms like nausea and vomiting.
Importantly, domperidone’s impact on the central nervous system is minimal because it poorly penetrates the blood-brain barrier. This reduces the likelihood of extrapyramidal side effects commonly associated with other antiemetics.
However, individual responses vary. Consult a healthcare professional for personalized guidance and to discuss potential interactions with other medications you are taking. They can help determine if domperidone is the right choice for you and monitor your progress.
Key takeaway: Domperidone works by specifically blocking dopamine receptors in the gut and CTZ, promoting improved gastrointestinal motility and reducing nausea and vomiting.
Note: This information is for educational purposes only and does not constitute medical advice. Always consult your doctor or pharmacist before starting any medication.
