Domperidone, often sold as Motilium, excels in treating nausea and vomiting caused by gastrointestinal issues, particularly delayed gastric emptying. However, it’s not a one-size-fits-all solution. Other antiemetics target different causes.
Ondansetron (Zofran) is frequently used for chemotherapy-induced nausea and vomiting. It powerfully blocks serotonin receptors in the brain, making it less effective for nausea from digestive problems. Side effects can include headaches and constipation.
Metoclopramide (Reglan), like domperidone, increases stomach motility. But it more often causes neurological side effects such as restlessness and dystonia (muscle spasms) at higher doses, limiting its long-term use.
Prochlorperazine (Compazine) is effective against various causes of nausea but carries a higher risk of sedation and extrapyramidal symptoms, potentially impacting motor control. It’s often used for severe nausea.
Promethazine (Phenergan) is a sedating antiemetic used for postoperative and motion sickness. While effective, it can cause drowsiness and dizziness.
The best choice depends on the cause of your nausea. If your symptoms stem from slow stomach emptying, domperidone might be a good option. For chemotherapy-related nausea, ondansetron is often preferred. Always consult your doctor to determine the most suitable antiemetic for your specific condition and health history. They can assess potential drug interactions and side effects based on your individual needs.
